Nature Medicine

The safety of supported psilocybin use in Oregon

We support the decriminalization of psychedelic use and the protection of Indigenous practices, but we believe that policies such as Oregon’s outpace evidence on psilocybin’s safety. Experts generally agree that psychedelics can be used safely under medical supervision. However, most trials have excluded people at risk for bipolar disorder, psychosis, suicidality and many physical conditions (including diabetes, arrhythmias, seizure disorders and cardiovascular conditions). Questions remain about how safety data from these trials may generalize outside carefully controlled research contexts; no data exist yet to support regulatory frameworks to ensure safety for psychedelic use.